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Vitamin D supplementation reduces risk of major cardiovascular events in older adults

This study evaluates whether Vitamin D supplementation reduces risk of major cardiovascular events in older adults.  Vitamin D has also been linked in studies to reduce inflammation and is so important to help live life well.

Why would this be important for people who live with trigeminal neuralgia?

Statics show that trigeminal neuralgia affects older females.  Females are often not aware of their risk factor around heart health and are more likely to be diagnosed with TN.

More than half a million women have cardiovascular disease

In 2017–18, an estimated 510,000 (4.8%) Australian women aged 18 and over had 1 or more heart, stroke and vascular diseases, based on self-reported data. About 206,000 women had coronary heart disease, and 37,000 had heart failure.

Cardiovascular disease in Australian women— a snapshot of national statistics

Cardiovascular disease (CVD) is the leading cause of death worldwide, yet important differences exist between men and women. Men generally develop CVD at a younger age and have a higher risk of coronary heart disease (CHD) than women. Women, in contrast, are at a higher risk of stroke, which often occurs at older age.

The incidence of TN was estimated to be 5.5 (95% confidence interval 4.7–6.4) per 100,000 person-years. The incidence increased with age, from 0.1 in 0- to 19-year-olds to 23.1 per 100,000 person-years in 80+-year-olds. Females exhibited a higher incidence at 7.3 than males at 3.7 per 100,000 person-years.20 Jan 2023

Background
Within the vascular system, most of the cells that express the vitamin D receptor also express 1α-hydroxylase and can convert 25-hydroxyvitamin D (25(OH)D) to calcitriol, the active form of vitamin D. Calcitriol has several
important biological functions including inflammation reduction, inhibition of
proliferation of vascular smooth muscle, and regulation of the renin-angiotensin-aldosterone system.
One meta-analysis of RCTs indicated that vitamin D supplementation was
ineffective in preventing cardiovascular events. However, this outcome was
contradicted by the Women’s Health Initiative Trial, which included women participants and a low dose of Vitamin D.
The D-Health Trial was launched to evaluate whether monthly vitamin D supplementation improves the health outcomes of older adults. Although a previous analysis using the D-Health cohort reported that vitamin D supplementation did not reduce mortality due to cardiovascular disease or all-cause mortality, their effect on the incidence of major cardiovascular events was not determined.

Read the full findings in the below research paper

Vitamin D supplementation reduces risk of major cardiovascular events in older adults

Further research Vitamin D and Inflammation

Vitamin D deficiency and C-reactive protein: a bidirectional Mendelian randomization study

A study from Ireland

Vitamin D status & associations with inflammation in older adults

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Vitamin D Deficiency Linked to Chronic Inflammation

We are always interested in research which can show what conditions may cause chronic inflammation

Australian Center for Precision Health, University of South Australia Cancer Research Institute,
Adelaide, Australia, 2
South Australian Health and Medical Research Institute, Adelaide, Australia and 3
Population, Policy and Practice, UCL Institute of Child Health, London, UK
*Corresponding author. Australian Center for Precision Health, University of South Australia Cancer Research Institute,
GPO Box 2471, Adelaide, SA 5001, Australia. E-mail: Elina.Hypponen@unisa.edu.au
Received 14 December 2021; Editorial decision 29 March 2022; Accepted 8 April 2022

 

Abstract
Background: Low vitamin D status is often associated with systemic low-grade inflam-
mation as reflected by elevated C-reactive protein (CRP) levels. We investigated the cau-
sality and direction of the association between vitamin D status and CRP using linear and non-linear Mendelian randomization (MR) analyses.

Methods: MR analyses were conducted using data from 294 970 unrelated participants
of White-British ancestry from the UK Biobank. Serum 25-hydroxyvitamin D [25(OH)D] and CRP concentrations were instrumented using 35 and 46 genome-wide significant variants, respectively.

Results: In non-linear MR analysis, genetically predicted serum 25(OH)D had an L-shaped
association with serum CRP, where CRP levels decreased sharply with increasing
25(OH)D concentration for participants within the deficiency range (<25 nmol/L) and lev-
elled off at – 50 nmol/L of 25(OH)D (Pnon-linear ¼ 1.49E-4).

Analyses using several pleiotropy-robust methods provided consistent results in stratified MR analyses, con-
firming the inverse association between 25(OH)D and CRP in the deficiency range
(P ¼ 1.10E-05) but not with higher concentrations. Neither linear or non-linear MR analysis supported a causal effect of serum CRP level on 25(OH)D concentration (Plinear ¼ 0.32 and Pnon-linear ¼ 0.76).
Conclusion: The observed association between 25(OH)D and CRP is likely to be caused by vitamin D deficiency.

Correction of low vitamin D status may reduce chronic inflammation.
Key words: Non-linear Mendelian randomization, vitamin D, serum 25-hydroxyvitamin D concentration, C-reactive
protein, chronic inflammation

 

The full study can be read below

Vitamin D deficiency and C-reactive protein: a bidirectional Mendelian randomization study