This study evaluates whether Vitamin D supplementation reduces risk of major cardiovascular events in older adults. Vitamin D has also been linked in studies to reduce inflammation and is so important to help live life well.
Why would this be important for people who live with trigeminal neuralgia?
Statics show that trigeminal neuralgia affects older females. Females are often not aware of their risk factor around heart health and are more likely to be diagnosed with TN.
In 2017–18, an estimated 510,000 (4.8%) Australian women aged 18 and over had 1 or more heart, stroke and vascular diseases, based on self-reported data. About 206,000 women had coronary heart disease, and 37,000 had heart failure.Cardiovascular disease in Australian women— a snapshot of national statistics
Cardiovascular disease (CVD) is the leading cause of death worldwide, yet important differences exist between men and women. Men generally develop CVD at a younger age and have a higher risk of coronary heart disease (CHD) than women. Women, in contrast, are at a higher risk of stroke, which often occurs at older age.
The incidence of TN was estimated to be 5.5 (95% confidence interval 4.7–6.4) per 100,000 person-years. The incidence increased with age, from 0.1 in 0- to 19-year-olds to 23.1 per 100,000 person-years in 80+-year-olds. Females exhibited a higher incidence at 7.3 than males at 3.7 per 100,000 person-years.20 Jan 2023
Within the vascular system, most of the cells that express the vitamin D receptor also express 1α-hydroxylase and can convert 25-hydroxyvitamin D (25(OH)D) to calcitriol, the active form of vitamin D. Calcitriol has several
important biological functions including inflammation reduction, inhibition of
proliferation of vascular smooth muscle, and regulation of the renin-angiotensin-aldosterone system.
One meta-analysis of RCTs indicated that vitamin D supplementation was
ineffective in preventing cardiovascular events. However, this outcome was
contradicted by the Women’s Health Initiative Trial, which included women participants and a low dose of Vitamin D.
The D-Health Trial was launched to evaluate whether monthly vitamin D supplementation improves the health outcomes of older adults. Although a previous analysis using the D-Health cohort reported that vitamin D supplementation did not reduce mortality due to cardiovascular disease or all-cause mortality, their effect on the incidence of major cardiovascular events was not determined.
Read the full findings in the below research paperVitamin D supplementation reduces risk of major cardiovascular events in older adults
Further research Vitamin D and InflammationVitamin D deficiency and C-reactive protein: a bidirectional Mendelian randomization study
A study from IrelandVitamin D status & associations with inflammation in older adults